Aging is a major risk factor for cognitive decline and increases the vulnerability of the brain to neurodegenerative diseases, such as Alzheimer’s disease (AD) which, in turn, dramatically accelerates the cognitive deterioration and risk for dementia. The biological pathways linking aging and AD are still poorly understood, partly due to the multitude of alterations induced by both processes. However, identifying biological processes operating at the intersection of aging and AD that convey downstream effects on cognitive decline could enhance our understanding of the aging brain. Furthermore, these processes could provide efficient and effective drug targets since their modulation would simultaneously affect two major determinants of dementia. To identify these processes, ADPriOMICs will combine extensive genome-wide genotype and gene expression data, sequencing information, proteomics, and deep phenotyping in longitudinal cognitive data using an unbiased approach.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.