Project information
CIISB - Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2023042
- Project Period
- 1/2023 - 12/2026
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Central European Institute of Technology
- Project Website
- https://www.ciisb.org/
- Cooperating Organization
-
Institute of Biotechnology CAS
- Responsible person Ing. Jan Dohnálek, PhD.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed national infrastructure, which consists of two nodes, one represented by CEITEC (Central European Institute of Technology, Brno) and second by BIOCEV (Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University, Vestec near Prague). CIISB offers access to 10 core facilities; five of them are part of the Centre of Structural Biology and one of the Mendel Centre of Genomics and Proteomics of Plants of CEITEC Masaryk University and four of the Centre of Molecular Structure of the Institute of Biotechnology AS CR in the BIOCEV Centre.
All CIISB core facilities are in the full operational phase. Projects as OP RDI (Start-up) supported the construction phase, and the built capacities were made available by both CIISB nodes in the form of Open Access to internal and external users. In its construction phase, CIISB (2011-2015) was the Associated National Center of the pan-European research infrastructure INSTRUCT. In 2016, following the completion, putting into operation, and subsequent international evaluation, CIISB became a fully-fledged Instruct-CZ Centre for this distributed infrastructure.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 104
2024
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Diterpenes Isolated from Three Different Plectranthus Sensu Lato Species and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells
ACS Omega, year: 2024, volume: 9, edition: 16, DOI
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Global interactome mapping reveals pro-tumorigenic interactions of NF-κB in breast cancer
Molecular and Cellular Proteomics, year: 2024, volume: 23, edition: 4, DOI
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Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3zeta protein variants
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, year: 2024, volume: 266, edition: Pt 2, DOI
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How does phosphorylation affect interaction between 14-3-3ζ and Tau proteins?
Year: 2024, type: Conference abstract
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In-cell NMR suggests that DNA i-motif levels are strongly depleted in living human cells
Nature Communications, year: 2024, volume: 15, edition: 1, DOI
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Lewis Acidic Aluminosilicates: Synthesis, 27Al MQ/MAS NMR, and DFT-Calculated 27Al NMR Parameters
Inorganic Chemistry, year: 2024, volume: 63, edition: 5, DOI
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Optimizing ChIRP-MS for Comprehensive Profiling of RNA-Protein Interactions in Arabidopsis thaliana: A Telomerase RNA Case Study
Plants, year: 2024, volume: 13, edition: 6, DOI
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pH-Dependent oligomerisation of γ-conglutin: A key element to understand its molecular mechanism of action
Food Hydrocolloids, year: 2024, volume: 147, edition: A, DOI
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Preparation of Alzheimer's-disease-relevant Tau protein in HEK293 mammalian cells
Year: 2024, type: Conference abstract
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Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer
Journal of Extracellular Vesicles, year: 2024, volume: 13, edition: 3, DOI