Project information
Alzheimer's Disease Diagnostics Innovation and Translation to Clinical Practice in Central Europe
(ADDIT-CE)
- Project Identification
- 101087124
- Project Period
- 1/2023 - 12/2026
- Investor / Pogramme / Project type
-
European Union
- Horizon Europe
- Widening participation and strengthening the European Research Area
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Project Website
- https://addit-ce.ceitec.cz/
- Cooperating Organization
-
St. Anne's University Hospital Brno
- Responsible person Katerina Sheardova
- Responsible person Mgr. Veronika Štěpánková, Ph.D.
- Responsible person Barbara Ukropcova
- Responsible person Norbert Žilka
Ministry of Health of the Slovak Republic
MultiplexDX
- Responsible person Adrián Szobi
- Responsible person Tomas Szemes
Česká alzheimerovská společnost, o.p.s.
- Responsible person Martina Mátlová
Dementia represents unmet medical need, more than 55 million of people suffer from this fatal disorder. Currently, there is no effective disease modifying therapy. Early diagnosis can significantly reduce total costs. Currently, there is no conceptual plan which would implement the modern diagnostic approaches into the clinical practise in Czech and Slovak republic. The interaction between universities and private sectors leading to the development of molecular diagnostic tools is fragmented and not properly organised. Limited number of talented students are interested in applied neuroscience research focusing on dementia. The main aim of the project is to create two inter-linked ecosystems, in Moravia and Bratislava region, which will encompass the whole quadruple helix of innovation driving actors: excellent scientific teams from Masaryk University and Slovak Academy of Sciences will collaborate with private biotech companies. The societal actors will be represented by organisations such as Slovak Alzheimer´s Society, Czech Alzheimer´s society, Centrum Memory and Czech Brain Aging Study. The regional government will be involved through Ministry of Health Slovak Republic, and South Moravian Innovation Centre. The interconnected ecosystems will unite the research and innovation activities focusing on new diagnostic methods and their applications and further interlink academia and business spheres by creating a pilot programme of industrial PhD positions for talented students. The project will generate a joint cross-border strategy covering basic and applied research activities in the field of Alzheimer Disease diagnostics, transfer new cutting-edge technologies into the clinical practise, and accelerate the development of new diagnostic tools for AD diagnostics. The project will join forces of all actors of the involved ecosystems to revolutionise the diagnostic approaches in both countries.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 14
2023
-
Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues
ChemCatChem, year: 2023, volume: 15, edition: 19, DOI
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Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate
Molecular Neurodegeneration, year: 2023, volume: 18, edition: 1, DOI
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Illuminating the mechanism and allosteric behavior of NanoLuc luciferase
Nature Communications, year: 2023, volume: 14, edition: 1, DOI
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Molecular dynamic simulation study of multiple phosphorylations at the proline rich region of tau(210-240) peptide
Year: 2023, type: Conference abstract