Project information
Telomere dynamics in selected types of solid malignant diseases

Project Identification

GA301/99/0045

Project Period

1/1999 - 1/2001

Investor / Pogramme / Project type

Czech Science Foundation

Standard Projects

MU Faculty or unit

Faculty of Science

Cooperating Organization

Institute of Biophysics

Responsible person prof. RNDr. Jiří Fajkus, CSc.

University Hospital Brno-Bohunice

Responsible person doc. RNDr. Lenka Fajkusová, CSc.
Responsible person prof. MUDr. Rostislav Vyzula, CSc.

Research Institute of Child Health Brno

Telomerase, a nucleoprotein enzyme complex, plays a crucial role in the development of cellular immortality and carcinogenesis. The project is focused on using activity and expression of telomerase in molecular diagnostics of cancer. The work on the pro ject will result in providing data on telomere dynamics in cancer tissue samples, as well as in optimising diagnostic methods and their introduction in oncolgy practice.

Publications

Total number of publications: 21

2006

Comparison of electromigration properties of stained microbial strains, cultured and from body fluids, in capillary electrophoreis

HORKÁ Marie RŮŽIČKA Filip HOLÁ Veronika ŠLAIS Karel HORKÝ Jaroslav

Article in Proceedings

20th Internat. Symposium on Microscale Bioseparations, MSB 2006, year: 2006

2003

The evaluation of left ventricular function in childhood cancer survivors by pharmacological stress echocardiography

ELBL Lubomír HRSTKOVÁ Hana CHALOUPKA Václav NOVOTNÝ Jan MICHALEK Jaroslav

Article in Periodical

Neoplasma, year: 2003, volume: 50, edition: 3

2002

Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology

FAJKUS Jiří ŠIMÍČKOVÁ Marta MALÁSKA Jan

Article in Periodical

Phil. Trans. R. Soc. Lond. B, year: 2002, volume: roč. 357, edition: April

2001

Columnar Structure Of Telomeric Chromatin

FAJKUS Jiří TRIFONOV Edward N.

Article in Proceedings

Journal of Biomolecular Structure and Dynamics, year: 2001
COLUMNAR STRUCTURE OF TELOMERIC CHROMATIN

FAJKUS Jiří SÝKOROVÁ Eva TRIFONOV Edward N.

Article in Proceedings

Role of Telomeres and Telomerase in Cancer and Aging, year: 2001
Early diagnosis and treatment of mycotic infection by PCR

DENDIS Milos HORVATH Radek MICHALEK Jaroslav RUZICKA Filip BENEDIK Jaroslav

Article in Periodical

Scripta Medica, year: 2001, volume: 74, edition: 3
Further characterization of telomeric chromatin

KUBIČÁROVÁ Tatiana

Article in Proceedings

Aktuální témata z buněčné a molekulární biologie, year: 2001
HODNOCENÍ TELOMERÁZOVÉ AKTIVITY A DÉLKY TELOMER U MNOHOČETNÉHO MYELOMU

MALÁSKA Jan FIŠEROVÁ Anežka KUNICKÁ Zuzana SKLENIČKOVÁ Marie KOVÁŘOVÁ Lenka BOURKOVÁ Ludmila MUSILOVÁ Romana HÁJEK Roman FAJKUS Jiří

Article in Proceedings

XV.OLOMOUCKÉ HEMATOLOGICKÉ DNY S MEZINÁRODNÍ ÚČASTÍ, year: 2001
In Situ Analysis of Telomeres in Haematological Malignancies

SKLENIČKOVÁ Marie KREJČÍ Kateřina MALÁSKA Jan FAJKUS Jiří

Article in Proceedings

European Journal of Human Genetics, year: 2001

2000

Detailed Mapping of Methylcythosine Positions at the CpG Island Surrounding tha Pa Promoter at the bcr-abl Locus in CML Patients in Two Cell Lines, K562 and BV 173

FAJKUSOVÁ Lenka FAJKUS Jiří POLÁČKOVÁ Klára FULNEČEK Jaroslav DVOŘÁKOVÁ Dana KRAHULCOVÁ Eva

Article in Periodical

Blood Cells, Molecules and Diseases, year: 2000, volume: 26, edition: 3