Go to main content | Go to main menu | Go to search

Project information
Nové mechanizmy vzniku fatálních kostních ciliopatií u člověka

Information

This project doesn't include Faculty of Science. It includes Faculty of Medicine. Official project website can be found on muni.cz.
Project Identification
LH15231
Project Period
1/2016 - 12/2017
Investor / Pogramme / Project type
Ministry of Education, Youth and Sports of the CR
  • KONTAKT II
MU Faculty or unit
Faculty of Medicine

The short rib polydactyly syndromes (SRPS) are frequently lethal conditions affecting skeletal development. Although they are broadly characterized as ciliopathies, most of the SRPS result from unknown biologic mechanisms. Elucidation of these mechanisms provides an invaluable opportunity to understand the primary cilia function. The team of Deborah Krakow at the University of California in Los Angeles has recently defined several SRPS genes in a cohort of 150 cases collected over the last 30 years. The team of Pavel Krejci at Masaryk University has developed novel experimental approaches to study the primary cilia, particularly focused on the skeleton. This project proposes a unique collaboration between two complementary teams to elucidate novel mechanisms in SRPS pathology.

Publications

Total number of publications: 10

2020

2019

2018

2017

2016

You are running an old browser version. We recommend updating your browser to its latest version.