Project information
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
- Project Identification
- MSM0021622430
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Other MU Faculty/Unit
- Central European Institute of Technology
- Keywords
- embryonic stem cells
The goal of this project will be a) to profit from availability of unique cellular resources - mouse and human embryonic stem cells and normal and malignant hematopoietic stem/progenitor cells, b) to effectively employ a wide variety of current and complementary methodologies available to the consortium, and c) to exploit a proven/certified expertise in working with various living systems that span from in vitro cultured cells, through animal models to oncohematological patients. All this together will represent a powerful experimental platform aimed at addressing a nature of molecules and molecular mechanisms underlaying phenomena that are common to both normal and cancer stem cells, mainly their ability to self-renew and to enter differentiation pathways. Integral part of this general goal is to implement multifaceted analytical approach that will cover studies of gene expression at both mRNA and protein levels, evaluating function of extra and intracellular signaling pathways, and analyzing biological properties of cells in vitro and in vivo. Expected outcome will be not only understanding but also a definition of molecules and/or molecular pathways to be tested as therapeutic targets, and cellular models that will make such testing feasible.
Publications
Total number of publications: 359
2009
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Inactivation of p53 and amplification of MYCN gene in a terminal lymphoblastic relapse in a chronic lymphocytic leukemia patient
Cancer Genetics and Cytogenetics, year: 2009, volume: 189, edition: 1
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Inhibition of canonical Wnt signaling promotes gliogenesis in P0-NSCs.
Biochemical and Biophysical Research Communications, year: 2009, volume: 386, edition: 4
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Intracoronary delivery of bone marrow cells to the acutely infarcted myocardium
Cardiology, year: 2009, volume: 112, edition: 2, DOI
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Lack of Population Diversity in Human Embryonic Stem-Cell Lines
New England Journal of Medicine, year: 2009, volume: 362, edition: 2
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MEK inhibition enhances BMS-214662-induced apoptosis in primitive CD34+ CML stem/progenitor cells.
Year: 2009, type: Conference abstract
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Microarray analysis using limited amount of cells
Folia Biologica (Praha), year: 2009, volume: 2009, edition: 55
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MicroRNA isolation and stability in stored RNA samples
Biochemical and Biophysical Research Communications, year: 2009, volume: 390, edition: 1
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MicroRNAs expression pattern in aggressive subtype of chronic lymphocytic leukemia
Year: 2009, type: Conference abstract
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MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtype.
LEUKEMIA & LYMPHOMA, year: 2009, volume: 50, edition: 3
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Mikrochimérismus - na hraně počínajícího relapsu AML?
Transfuze a hematologie dnes, year: 2009, volume: 15, edition: 2