Project information
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
- Project Identification
- MSM0021622430
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Other MU Faculty/Unit
- Central European Institute of Technology
- Keywords
- embryonic stem cells
The goal of this project will be a) to profit from availability of unique cellular resources - mouse and human embryonic stem cells and normal and malignant hematopoietic stem/progenitor cells, b) to effectively employ a wide variety of current and complementary methodologies available to the consortium, and c) to exploit a proven/certified expertise in working with various living systems that span from in vitro cultured cells, through animal models to oncohematological patients. All this together will represent a powerful experimental platform aimed at addressing a nature of molecules and molecular mechanisms underlaying phenomena that are common to both normal and cancer stem cells, mainly their ability to self-renew and to enter differentiation pathways. Integral part of this general goal is to implement multifaceted analytical approach that will cover studies of gene expression at both mRNA and protein levels, evaluating function of extra and intracellular signaling pathways, and analyzing biological properties of cells in vitro and in vivo. Expected outcome will be not only understanding but also a definition of molecules and/or molecular pathways to be tested as therapeutic targets, and cellular models that will make such testing feasible.
Publications
Total number of publications: 359
2011
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A novel method for detection of NON-MTC breakpoints in mantle cell lymphoma patients.
Year: 2011, type: Conference abstract
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Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P(2) to LRP6 phosphorylation.
The EMBO journal, year: 2011, volume: 30, edition: 8, DOI
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Analysis of phenotype of cells in primary cultures derived from lymph node biopsies of patients with lymphomas.
Year: 2011, type: Conference abstract
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Analysis of potentially biclonal CLL patients with two or three productive IGH rearrangements.
Year: 2011, type: Conference abstract
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Analýza biklonálních /bifenotypických případů chronické lymfocytární leukemie.
Year: 2011, type: Conference abstract
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Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2
Neoplasia, year: 2011, volume: 13, edition: 6, DOI
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Assessment of adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) mRNA expression in patients with de novo chronic myelogenous leukemia: the role of different cell types.
Leukemia & Lymphoma, year: 2011, volume: 52, edition: 2, DOI
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CD133 expression and identification of CD133/nestin positive cells in rhabdomyosarcomas and rhabdomyosarcoma cell lines
Analytical Cellular Pathology-Cellular Oncology, year: 2011, volume: 34, edition: 6, DOI
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Clinical and laboratory features of leukemias at the time of diagnosis: An analysis of 1,004 consecutive patients
American Journal of Hematology, year: 2011, volume: 86, edition: 9, DOI
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Concentration of selected cytokines in bone marrow and peripheral blood of patients with lymphoma.
Year: 2011, type: Conference abstract