Mgr. Jan Brezovský, Ph.D.

2018

• Exploration of Enzyme Diversity by Integrating Bioinformatics with Expression Analysis and Biochemical Characterization

  VAŇÁČEK Pavel ŠEBESTOVÁ Eva BABKOVÁ Petra NEVOLOVÁ Šárka DANIEL Lukáš DVOŘÁK Pavel ŠTĚPÁNKOVÁ Veronika CHALOUPKOVÁ Radka BREZOVSKÝ Jan PROKOP Zbyněk DAMBORSKÝ Jiří

  Article in Periodical

  ACS Catalysis, year: 2018, volume: 8, edition: 3, DOI

• Impact of the access tunnel engineering on catalysis is strictly ligand-specific

  KAUSHIK Shubhangi MARQUES Sérgio Manuel KHIRSARIYA Prashant Kumar PARUCH Kamil LIBICHOVÁ Lenka BREZOVSKÝ Jan PROKOP Zbyněk CHALOUPKOVÁ Radka DAMBORSKÝ Jiří

  Article in Periodical

  the FEBS Journal, year: 2018, volume: 285/2018, edition: 8, DOI

• Molecular Gating of an Engineered Enzyme Captured in Real Time

  KOKKONEN Piia Pauliina SYKORA J. PROKOP Zbyněk GHOSE A. BEDNÁŘ David AMARO M. BEERENS Koen NEVOLOVÁ Šárka SLÁNSKÁ Michaela BREZOVSKÝ Jan DAMBORSKÝ Jiří HOF M.

  Article in Periodical

  Journal of the American Chemical Society, year: 2018, volume: 140, edition: 51, DOI

• Pyrazolotriazines as inhibitors of nucleases

  DAMBORSKÝ Jiří NIKULENKOV Fedor SISÁKOVÁ Alexandra HAVEL Štěpán KREJČÍ Lumír CARBAIN Benoit, Jean-Pierre BREZOVSKÝ Jan DANIEL Lukáš PARUCH Kamil

  Patent

  Publisher: Japan Patent Office, state: Japan, patent's number: JP 6313906, year: 2018

• Pyrazolotriazines as inhibitors of nucleases

  DAMBORSKÝ Jiří NIKULENKOV Fedor SISÁKOVÁ Alexandra HAVEL Štěpán KREJČÍ Lumír CARBAIN Benoit Jean-Pierre BREZOVSKÝ Jan DANIEL Lukáš PARUCH Kamil

  Patent

  Publisher: USPTO, state: United States of America, patent's number: US 9969741 B2, year: 2018

2017

• Ancestral Haloalkane Dehalogenases Show Robustness and Unique Substrate Specificity

  BABKOVÁ Petra ŠEBESTOVÁ Eva BREZOVSKÝ Jan CHALOUPKOVÁ Radka DAMBORSKÝ Jiří

  Article in Periodical

  CHEMBIOCHEM, year: 2017, volume: 18, edition: 14, DOI

• Catalytic Cycle of Haloalkane Dehalogenases Toward Unnatural Substrates Explored by Computational Modeling

  MARQUES Sérgio Manuel DUNAJOVÁ Zuzana PROKOP Zbyněk CHALOUPKOVÁ Radka BREZOVSKÝ Jan DAMBORSKÝ Jiří

  Article in Periodical

  JOURNAL OF CHEMICAL INFORMATION AND MODELING, year: 2017, volume: 57, edition: 8, DOI

• CaverDock 1.0

  FILIPOVIČ Jiří VÁVRA Ondřej PLHÁK Jan BEDNÁŘ David MARQUES Sérgio Manuel BREZOVSKÝ Jan MATYSKA Luděk DAMBORSKÝ Jiří

  Year: 2017

• Computational Analysis of Protein Tunnels and Channels

  BREZOVSKÝ Jan KOZLÍKOVÁ Barbora DAMBORSKÝ Jiří

  Chapter of a book

  PROTEIN ENGINEERING. METHODS AND PROTOCOLS, year: 2017, number of pages: 18 s.

• Different Structural Origins of the Enantioselectivity of Haloalkane Dehalogenases toward Linear beta-Haloalkanes: Open–Solvated versus Occluded–Desolvated Active Sites

  LIŠKOVÁ Veronika ŠTĚPÁNKOVÁ Veronika BEDNÁŘ David BREZOVSKÝ Jan PROKOP Zbyněk CHALOUPKOVÁ Radka DAMBORSKÝ Jiří

  Article in Periodical

  Angewandte Chemie International Edition, year: 2017, volume: 56, edition: 17, DOI