Mgr. Pavlína Janovská, Ph.D.

2024

• Unveiling the dynamics and molecular landscape of a rare chronic lymphocytic leukemia subpopulation driving refractoriness: insights from single-cell RNA sequencing

  KURUCOVÁ Terézia RÉBLOVÁ Kamila JANOVSKÁ Pavlína PORC Jakub Paweł NAVRKALOVÁ Veronika PAVLOVÁ Šárka MALČÍKOVÁ Jitka PLEVOVÁ Karla TICHÝ Boris DOUBEK Michael BRYJA Vítězslav KOTAŠKOVÁ Jana POSPÍŠILOVÁ Šárka

  Article in Periodical

  Molecular oncology, year: 2024, DOI

2023

• 4-(1H-IMIDAZOL-5-YL)-1H-PYRROLO [2,3-B] PYRIDINES FOR USE IN THE TREATMENT OF LEUKAEMIAS, LYMPHOMAS AND SOLID TUMORS

  BRYJA Vítězslav JANOVSKÁ Pavlína GREGOROVÁ Michaela NĚMEC Václav KHIRSARIYA PrashantKumar PARUCH Kamil

  Patent

  Publisher: China National Intellectual Property Administration, state: China, patent's number: CN111936496, year: 2023

• Direct co-culture model of chronic lymphocytic leukaemia: CK1 inhibition counteracts the protective effect of bone marrow stromal cells.

  PLEŠINGEROVÁ Hana JANOVSKÁ Pavlína RADOVÁ Lenka MAŘÁKOVÁ M KOTAŠKOVÁ J HANKEOVÁ Simona ANDERSSON BRYJA

  Conference abstract

  Year: 2023, type: Conference abstract

• Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity

  NĚMEC Václav KHIRSARIYA PrashantKumar JANOVSKÁ Pavlína MARTÍN MOYANO Paula MAIER Lukáš PROCHÁZKOVÁ Petra KEBKOVÁ Pavlína GYBEĽ Tomáš BERGER Benedict-Tilman CHAIKUAD Apirat REINECKE Maria KUSTER Bernhard KNAPP Stefan BRYJA Vítězslav PARUCH Kamil

  Article in Periodical

  Angewandte Chemie International Edition, year: 2023, volume: 62, edition: 11, DOI

• Perturbance of B cell subsets in MBL and CLL patients

  VONDÁLOVÁ BLANÁŘOVÁ Olga MIKULOVÁ Antónia PLEŠINGEROVÁ Hana STANČÍKOVÁ Jana ARPÁŠ Tomáš KALINA T. KOTAŠKOVÁ Jana BRYJA Vítězslav JANOVSKÁ Pavlína

  Conference abstract

  Year: 2023, type: Conference abstract

• The role of casein kinase 1 inhibition in treatment of chronic lymphocytic leukemia.

  MIKULOVÁ Antónia JANOVSKÁ Pavlína VERNER Jan PLEŠINGEROVÁ Hana VONDÁLOVÁ BLANÁŘOVÁ Olga KEBKOVÁ Pavlína SOTOLÁŘOVÁ Kateřina BARTOŠÍKOVÁ Jana CHORVÁTOVÁ M. KURUCOVÁ Terézia LOJA Tomáš TICHÝ Boris KUBALA Lukáš BRYJA Vítězslav

  Conference abstract

  Year: 2023, type: Conference abstract

2022

• 4-(1h- imidazol- 5- yl) -1h-pyrrolo [2, 3-b] pyridines for use in the treatment of leukaemias, lymphomas and solid tumors

  BRYJA Vítězslav JANOVSKÁ Pavlína GREGOROVÁ Michaela NĚMEC Václav KHIRSARIYA PrashantKumar PARUCH Kamil

  Patent

  Publisher: Canadian Intellectual Property Office, state: Canada, patent's number: CA3085967, year: 2022

• 4-(1h- imidazol- 5- yl) -1h-pyrrolo [2, 3-b] pyridines for use in the treatment of leukaemias, lymphomas and solid tumors

  BRYJA Vítězslav JANOVSKÁ Pavlína GREGOROVÁ Michaela NĚMEC Václav KHIRSARIYA PrashantKumar PARUCH Kamil

  Patent

  Publisher: European Patent Office, state: Germany, patent's number: EP3774795, year: 2022

• 4-(1H-imidazol-5-yl)-1H-pyrrolo[2, 3-b] pyridines for use in the treatment of leukaemias, lymphomas and solid tumors

  BRYJA Vítězslav JANOVSKÁ Pavlína GREGOROVÁ Michaela NĚMEC Václav KHIRSARIYA PrashantKumar PARUCH Kamil

  Patent

  Publisher: United States Patent and Trademark Office, state: United States of America, patent's number: US11498920, year: 2022

• Interrogating the molecular heterogeneity of chronic lymphocytic leukemia through computational approaches.

  TAUŠ Petr KURUCOVÁ Terézia ZÁVACKÁ Kristýna PÁL Karol VALIŠOVÁ Martina KOTAŠKOVÁ Jana POSPÍŠILOVÁ Šárka BRYJA Vítězslav JANOVSKÁ Pavlína PLEVOVÁ Karla

  Conference abstract

  Year: 2022, type: Conference abstract