doc. Mgr. Kamil Paruch, Ph.D.

2012

• Inhibition of Chk1 kinase sensitizes leukemia and lymphoma cell lines with TP53 mutations to chemotherapy

  ZEMANOVÁ Jana ŠEBEJOVÁ Ludmila HYLSE Ondřej PARUCH Kamil PAVLOVÁ Šárka MAYER Jiří POSPÍŠILOVÁ Šárka TRBUŠEK Martin

  Conference abstract

  Year: 2012, type: Conference abstract

2011

• Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1.

  DWYER Michael PARUCH Kamil LABROLI Marc ALVAREZ Carmen KEERTIKAR Kerry POKER Cory ROSSMAN Randall FISCHMANN Thierry DUCA Jose MADISON Vincent PARRY David DAVIS Nicole SEGHEZZI Wolfgang WISWELL Derek GUZI Timothy

  Article in Periodical

  Bioorganic & Medicinal Chemistry Letters, year: 2011, volume: 21, edition: 1

• Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 2.

  DWYER Michael PARUCH Kamil LABROLI Marc ALVAREZ Carmen KEERTIKAR Kerry POKER Cory ROSSMAN Randall FISCHMANN Thierry DUCA Jose MADISON Vincent PARRY David DAVIS Nicole SEGHEZZI Wolfgang WISWELL Derek GUZI Timothy

  Article in Periodical

  Bioorganic & Medicinal Chemistry Letters, year: 2011, volume: 21, edition: 1, DOI

• IVth Conference on Heterocycles in Bio-organic Chemistry - Bioheterocycles 2011

  POTÁČEK Milan PARUCH Kamil

  Conference

  Year: 2011, type: Conference

• Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening

  GUZI Timothy J. PARUCH Kamil DWYER Michael P. LABROLI Marc SHANAHAN Frances DAVIS Nicole TARICANI Lorena WISWELL Derek SEGHEZZI Wolfgang PENAFLOR Ervin BHAGWAT Bhagyashree WANG Wei GU Danling HSIEH Yunsheng LEE Suining LIU Ming PARRY David

  Article in Periodical

  Molecular Cancer Therapeutics, year: 2011, volume: 10, edition: 4, DOI

2010

• Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor

  PARRY David GUZI Timothy SHANAHAN Frances DAVIS Nicole PRABHAVALKAR Deepa WISWELL Derek SEGHEZZI Wolfgang PARUCH Kamil DWYER Michael DOLL Ronald NOMEIR Amin WINDSOR William FISCHMANN Thierry WANG Yaolin OFT Martin CHEN ´Taiying KIRSCHMEIER Paul LEES Emma

  Article in Periodical

  Molecular Cancer Therapeutics, year: 2010, volume: 2010, edition: 8

• Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases.

  PARUCH Kamil DWYER Michael ALVAREZ Carmen BROWN Courtney CHAN Tin-Yau DOLL Ronald KEERTIKAR Kerry KNUTSON Chad MCKITTRICK Brian RIVERA Jocelyn ROSSMAN Randall TUCKER Greg FISCHMANN Thierry HRUZA Alan MADISON Vincent NOMEIR Amin WANG Yaolin KIRSCHMEIER Paul LEES Emma PARRY David SGAMBELLONE Nicole SEGHEZZI Wolfgang SCHULTZ Lesley SHANAHAN Frances WISWELL derek XU Xiaoying ZHOU Quiao JAMES Ray PARADKAR Vidyadhar PARK Haengsoon ROKOSZ Laura STAUFFER Tara GUZI Timothy

  Article in Periodical

  ACS Medicinal Chemistry Letters, year: 2010, volume: 2010, edition: 5

2009

• 2-Fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors

  PARUCH Kamil GUZI Timothy DWYER Michael

  Patent

  Publisher: World Intellectual Property Organization, state: United States of America, patent's number: WO 2009/070567 A1, year: 2009

• Novel modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors

  GUZI Timothy PARRY David LABROLI Marc DWYER Michael PARUCH Kamil ROSNER Kristen SHEN Ruichao POPOVICI-MULLER Janeta

  Patent

  Publisher: World Intellectual Property Organization, state: United States of America, patent's number: WO 2009/061781 A1, year: 2009

2008

• Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

  GUZI Timothy PARUCH Kamil DOLL Ronald GIRIJAVALLABHAN Viyyoor MALLAMS Alan ALVAREZ Carmen KEERTIKAR Kartik RIVERA Jocelyn CHAN Tin-Yau MADISON Vincent FISCHMANN Thierry KIRSCHMEIER Paul BANNERJI Rajat DILLARD Lawrence TRAN Vinh HE Zhenmin JAMES Ray PARK Haengsoon PARADKAR Vidyadhar HOBBS Douglas

  Patent

  Publisher: World Intellectual Property Organization, state: United States of America, patent's number: WO 2008/130570 A1, year: 2008