Informace o projektu
Capillary electrophoresis as a member of the metabolomic analytical toolbox
(CE metabolomics)
- Kód projektu
- GAP206/11/0009
- Období řešení
- 1/2011 - 12/2015
- Investor / Programový rámec / typ projektu
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Grantová agentura ČR
- Standardní projekty
- Fakulta / Pracoviště MU
- Přírodovědecká fakulta
- Další fakulta/pracoviště MU
- Lékařská fakulta
The generic methods for metabolomic studies based on application of different CE modes - capillary zone electrophoresis (CZE), micellar electrokinetic capillary chromatography (MEKC), microemulsion electrokinetic capillary chromatography (MEEKC), nonaqueous capillary electrophoresis (NACE) for corresponding metabolite classes will be developed. The relevant on-line preconcentration strategies will be integrated in given methods and possibility of using with MS detection will be tested. They can be used for metabolite fingerprinting and footprinting, metabolite profiling as well as target analysis. The complete procedure for the target metabolome analysis of microbial samples thus will be available starting from the rapid metabolism quenching and the quantitative extraction of selected metabolites up to their analysis by different CE modes. Besides the new method for the embryo viability testing based on non-invasive metabolite footprinting and profiling will be available as well.
Publikace
Počet publikací: 46
2013
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Amino acid profiling of human plasma samples using capillary electrophoresis with contactless conductivity detection
CHEMICKE LISTY, rok: 2013, ročník: 107, vydání: S3
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Amino Acids Profiling for Supplementary Diagnostic Purposes Based on Capillary Electrophoresis with Contactless Conductivity Detection
Rok: 2013, druh: Konferenční abstrakty
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Application of short-end injection procedure in capillary electrophoresis
Electrophoresis, rok: 2013, ročník: 34, vydání: 5, DOI
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Capillary electrophoresis with contactless conductivity detection for amino acid profiling of human plasma and urine samples
Chemické listy, rok: 2013, ročník: 107, vydání: S3
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Determination of asymmetric and symmetric dimethylarginines in human plasma using high-performance liquid chromatography with electrochemical detection
Journal of Separation Science, rok: 2013, ročník: 36, vydání: 23, DOI
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Naphthalene-2,3-dicarbaldehyde derivatization of amino acids - an improved technique for minimization of benzoin condensation
Chemické listy, rok: 2013, ročník: 107, vydání: S3
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Nonlinear Regression Models for Determination of Nicotinamide Adenine Dinucleotide Content in Human Embryonic Stem Cells
Stem Cell Reviews and Reports, rok: 2013, ročník: 9, vydání: 6, DOI
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RECEPTIVITA ENDOMETRIA V ASISTOVANÉ REPRODUKCI
Gynekológia pre prax, rok: 2013, ročník: 11, vydání: 4
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Simultaneous quantification of energetically important metabolites in various cell types by capillary zone electrophoresis
Journal of Separation Science, rok: 2013, ročník: 36, vydání: 23, DOI
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Study of the most common additives affecting electro-osmotic flow for use in capillary electrophoresis with contactless conductivity detection setup
Chemické listy, rok: 2013, ročník: 107, vydání: S3