Ongoing Projects:
National Institute for Cancer Research (NÚVR), LX22NPO5102 , Co-investigator: Vítězslav Bryja, Project period: 6/2022 – 12/2025, Investor: Ministry of Education, Youth and Sports of the Czech Republic Understanding Cell Compartment and Liquid Phase Restricted Functions of Dishevelled, GA22-25365S , Principal investigator: Vítězslav Bryja, Project period: 1/2022 – 12/2024, Investor: Czech Science Foundation Molecular and Functional Analysis of Casein Kinase 1 Biology, GX19-28347X , Principal investigator: Vítězslav Bryja, Project period: 1/2019 – 12/2023, Investor: Czech Science Foundation Preclinical Progression of New Organic Compounds with Targeted Biological Activity (Preclinprogress), CZ.02.1.01/0.0/0.0/16_025/0007381 , Principal investigator: Kamil Paruch, Project period: 8/2018 — 12/2022, Investor: Ministry of Education, Youth and Sports of the Czech Republic
Finished Projects:
Solving the WNT pathway mystery by the analysis of Dishevelled structure, GA18-17658S , Principal investigator: Vítězslav Bryja, Project period: 1/2018 – 12/2020, Investor: Czech Science Foundation Wnt signaling in the Pathogenesis of Ovarian Cancer, MUNI/E/0532/2019 , Principal investigator: Vendula Pospíchalová, Project period: 6/2019 – 12/2019, Investor: Masaryk University / Grant Agency of the Masaryk University Computational chemistry for Wnt signaling pathway, MUNI/G/1100/2016 , Principal investigator: Vítězslav Bryja, Project period: 3/2017 – 12/2019, Investor: Masaryk University / Grant Agency of the Masaryk University Functional and biochemical characterization of extracellular vesicles from ovarian cancer ascites, 17-11776Y , Principal investigator: Vendula Pospíchalová, Project period: 1/2017 — 12/2019, Investor: Czech Science Foundation Novel readouts for the planar cell polarity (PCP) pathway, 17‑16680S , Principal investigator: Vítězslav Bryja, Project period: 1/2017-12/2019, Investor: Czech Science Foundation Study of conformational dynamics of Disheveled 3 protein by FRET sensors: discovery of the key role of casein kinase 1 (CK1), MUNI/E/0533/2018 , Principal investigator: Jakub Harnoš, Vítězslav Bryja, Project period: 5/2018 – 4/2019, Investor: Masaryk University / Grant Agency of the Masaryk University Are morphogens of the Wnt family hormones? , Principal investigator: Vítězslav Bryja, Project period: 1/2017-12/2018, Investor: Neuron – Fund for Support of Science Analysis of the Wnt/PCP pathway for better management of chronic lymphocytic leukemia, 15-29793A , Principal investigator: Vítězslav Bryja, Project period: 5/2015-12/2018, Investor: Ministry of Health of the Czech Republic Casein Kinase 1 is a Therapeutic Target in Chronic Lymphocytic Leukemia, MUNI/E/0102/2017 , Principal investigator: Pavlína Janovská, Project period: 4/2017 — 12/2017, Investor: Grant Agency of Masaryk University Secretion and signaling of Wnt ligands in the development of the central nervous system, MUNI/E/0965/2016 , Principal investigator: Karol Kaiser, Project period: 1/2017 — 12/2017, Investor: Grant Agency of Masaryk University Automatized analysis of electron microscopy images for use in biology and medicine, MUNI/M/1050/2013 , Principal investigator: Pavel Matula, Project period: 3/2014-12/2016, Investor: Grant Agency of Masaryk UniversityWNT-mediated signal relay in stem cells and oncogenesis – from basic biology to applications, 608180 , Principal investigator: Vítězslav Bryja, Project period: 8/2013-7/2017, Investor: European Comission FP7 (Marie Curie International Training Network) Cooperation between Masaryk University and Karolinska Institutet, Stockholm in the field of biomedicine, CZ.1.07/2.3.00/20.0180 , Project period: 7/2012-6/2015, Investor: Ministry of Education, Youth and Sports of the Czech RepublicMolecular mechanisms of non-canonical Wnt signaling in leukemia, GAP301/11/0747 , Principal investigator: Vítězslav Bryja, Project period: 1/2011-12/2014, Investor: Czech Science Foundation Dynamics of proteins interacting with Dishevelled and their importance for Wnt signaling, GA204/09/0498 , Principal investigator: Vítězslav Bryja, Project period: 1/2009-12/2013, Investor: Czech Science Foundation The role of beta-arrestin in achieving Wnt signalling specificity, Principal investigator: Vítězslav Bryja, Project period: 1/2009-12/2011, Investor: Czech Science Foundation Intercellular signaling in development and disease, GD204/09/H058 , Principal investigator: Vítězslav Bryja, Project period: 1/2009-12/2012, Investor: Czech Science Foundation Frizzled signaling – protein-protein interactions and intracellular scaffolding as a means of signal transduction, YR2007-7014 , Principal investigator: Vítězslav Bryja, Project period: 1/2008-12/2012, Investor: The Swedish Foundation for International Cooperation in Research and Higher Education (STINT) Posttranslational modification of Dishevelled, KJB501630801 , Principal investigator: Vítězslav Bryja, Project period: 1/2008-12/2010, Investor: Grant Agency of the Academy of Sciences of the Czech Republic Functional analysis of dishevelledome, Principal investigator: Vítězslav Bryja, Project period: 1/2008-12/2012, Investor: EMBO Installation Grant Functional and molecular characteristics of cancer and normal stem cells – identification of targets for novel therapeutics and therapeutic strategies, Principal investigator: Vítězslav Bryja, Project period: 1/2007-12/2013, Investor: Ministry of Education, Youth and Sports of the Czech Republic
