News

In mid-September, the Bryjalab team embarked on their traditional annual Lab Retreat, this year held in a new location – Heroltice. Team-building activities included a mushroom hunting which ended up rather like mycological excursion, cooking together, a barbecue, and singing … Read More

Happy to announce that our latest article „Proteomic Analysis of Ascitic Extracellular Vesicles Describing Tumor Microenvironment and Predicting Patient Survival in Ovarian Cancer„, has just been published in Journal of Extracellular Vesicles! 🎉 This groundbreaking research delves into the intricate … Read More

The new AKTA chromatography system has strengthened our laboratory possibilities and capacities! The first protein purification and extremely immediately successful!

Abstract: Mineralized tissues, such as bones or teeth, are essential structures of all vertebrates. They enable rapid movement, protection, and food processing, in addition to providing physiological functions. Although the development, regeneration, and pathogenesis of teeth and bones have been … Read More

Abstract: In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik/C14orf105/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusually high evolutionary divergence in birds and … Read More

Laboratories of Dr. Konstantinos Tripsianes (CEITEC MU) and Prof. Vítězslav Bryja (Faculty of Science MU) are looking for new colleagues: (i) Research technician workload: 40 hours per week work tasks:  a) general molecular biology tasks: DNA and protein analysis, transformation, … Read More

We cordially invite you to a lecture: Cytonemes in cell signalling – Spreading Wnt signals in development and disease

Abstract: Casein kinases 1 (CK1) are key signaling molecules that have emerged recently as attractive therapeutic targets in particular for the treatment of hematological malignancies. Herein, we report the identification of a new class of potent and highly selective inhibitors … Read More

Abstract: The migratory properties of leukemic cells are commonly associated with their pathological potential and can significantly affect the disease progression. While the research in immunopathology mostly employed powerful indirect methods such as flow cytometry, these cells were rarely observed … Read More

Abstract: Spontaneous bleeds are a leading cause of death in the pediatric JAG1-related liver disease Alagille syndrome (ALGS). We asked whether there are sex differences in bleeding events in patients, whether Jag1Ndr/Ndr mice display bleeds or vascular defects, and whether … Read More

Darja Klementová, talented high-school student working in our laboratory, has been awarded “Česká hlavička” Award for young gifted students in technical and natural sciences. Congratulations! 🍀 Darja has been awarded for her work focused on casein kinases. Her work was … Read More

Abstract: Over the past decades an extensive effort has been made to provide a more comprehensive understanding of Wnt signaling, yet many regulatory and structural aspects remain elusive. Among these, the ability of Dishevelled (DVL) protein to relocalize at the … Read More

Abstract: The choroid plexus (ChP) is an extensively vascularized tissue that protrudes into the brain ventricular system of all vertebrates. This highly specialized structure, consisting of the polarized epithelial sheet and underlying stroma, serves a spectrum of functions within the … Read More

Abstract: Luciferase reporter assays represent a simple and sensitive experimental system in cell and molecular biology to study multiple biological processes. However, the application of these assays is often limited by the costs of conventional luminometer instruments and the versatility … Read More

Abstract: Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of ROR1, the cell surface receptor for Wnt-5a. Both, BCR and ROR1 are therapeutic … Read More

On the occasion of the Business Research Forum – the trade fair for cooperation between Masaryk University and business field, Masaryk University awarded the exceptional innovative achievements of its researchers. Masaryk University awarded achievements in research that have been successfully … Read More

The Neuron Endowment Fund awarded the Neuron Prizes on Tuesday, September 28, in the Pantheon of the National Museum. The awards were given in the categories of lifelong contribution to science, young promising scientists and for the first time, also … Read More

Abstract: WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical β-catenin-independent signaling pathway and often … Read More

We cordially welcome new students in Bryjalab! Hope you will enjoy your first steps in the world of science! 🍀

Our students succeeded with their research work and received the Dean’s Award! Congratulations to all and thank you for the great representation of the OFIŽ! 🍀👏   In the category of the best students of bachelor’s and master’s programs, the … Read More

Peťa Paclíková successfully completed her journey to a doctoral degree!

Abstract: Dishevelled (DVL) proteins are key mediators of most Wnt pathways. In all vertebrates, three DVL paralogs are present (DVL1, DVL2 and DVL3) but it is poorly defined to what extent they are functionally redundant. Here, we generated T-REx HEK … Read More

Abstract: The choroid plexus (ChP) produces cerebrospinal fluid and forms an essential brain barrier. ChP tissues form in each brain ventricle, each one adopting a distinct shape, but remarkably little is known about the mechanisms underlying ChP development. Here, we … Read More

The Sokol laboratory at the Icahn School of Medicine at Mount Sinai, New York, is looking for a motivated candidate to join their research group as a research fellow in the spring/summer of 2021. The laboratory studies how Wnt and … Read More

Abstract: The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. Authors: Neil Dani … Read More

Our article has been chosen by the Development editor Paola Arlotta (Harvard Stem Cell Institute) and selected for the monthly webinar „Development presents ….“ ! The topic will be introduced by the first author Karol Kaiser, Ph.D.: „MEIS-WNT5A axis regulates … Read More

We cordially invite you to the Wnttalks, where our alumni Karol Kaiser, Ph.D. will present his research from Bryjalab that was focused on Wnt5 and choroid plexus in a talk: Meis1-Wnt5a axis – The story of two choroid plexuses. 6. … Read More

Abstract: Primary cilia act as crucial regulators of embryo development and tissue homeostasis. They are instrumental for modulation of several signaling pathways, including Hedgehog, WNT, and TGF-β. However, gaps exist in our understanding of how cilia formation and function is … Read More

Abstract: Organ function depends on tissues adopting the correct architecture. However, insights into organ architecture are currently hampered by an absence of standardized quantitative 3D analysis. We aimed to develop a robust technology to visualize, digitalize, and segment the architecture … Read More

Faculty of Science MUNI has recently prepared an interview with Vita Bryja as a part of „Success Stories“ series of scientists at the faculty.

Abstract: The PDZ domain of Dishevelled 3 protein belongs to a highly abundant protein recognition motif which typically binds short C-terminal peptides. The affinity of the PDZ towards the peptides could be fine-tuned by a variety of post-translation modifications including … Read More

A new spin-off company, CasInvent Pharma, a.s., has been established by Masaryk University (MU) in cooperation with its investment partner, i&i Prague, s.r.o. (Ltd), in order to facilitate further development of new compounds that could be used to treat certain … Read More

Selected scientists from Masaryk University were awarded for their outstanding research results and significant achievements in the field of research from 2019 to 2020 by the Vice-Rector for Research and Doctoral Studies prof. Šárka Pospíšilová. Later, they have managed to … Read More

The casein kinase 1 enzymes (CK1) form a family of serine/threonine kinases with seven CK1 isoforms identified in humans. The most important substrates of CK1 kinases are proteins that act in the regulatory nodes essential for tumorigenesis of hematological malignancies. … Read More

Tomek Radaszkiewicz successfully completed his journey to a doctoral degree!

A comprehensive review on choroid plexus and its regulatory role in CNS by Karol Kaiser, Ph.D. just published in International Journal of Molecular Sciences! Follow us on Twitter. 😉

Congratulations! On Tuesday, Zankruti successfully completed her journey to a doctoral degree! Her PhD defense took place online but we all managed it and enjoyed fruitful and stimulating discussion! We wish Zankruti the BEST OF LUCK with her postdoc position … Read More

Another paper out and another step closer to a better understanding of #RNF43 tumor #suppressor action thanks to Tomek Radaszkiewicz!   Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells Cell Commun … Read More

Students of our department succeeded with their work and received the Dean’s Awards! Congratulations to all & thank you for the great representation of the department! In the category of the best students of bachelor’s and master’s programs: Mgr. Tomáš … Read More

ABSTRACT: Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of the cell surface receptor ROR1. Both, BCR and ROR1 are therapeutic targets in … Read More

Development 2020 147: dev186338 ABSTRACT: Directional migration during embryogenesis and tumor progression faces the challenge that numerous external signals need to converge to precisely control cell movement. The Rho guanine exchange factor (GEF) Trio is especially well suited to relay … Read More

Just posted: MEIS-Wnt5a axis revealed as regulator of choroid plexus development ABSTRACT: The choroid plexus (ChP) produces cerebrospinal fluid and forms a critical barrier between the brain and the circulation. While the ChP forms in each brain ventricle, it adopts … Read More

Cells 2020, 9(5), 1147. ABSTRACT: Wnt and BMP signaling pathways are two key molecular machineries regulating development and homeostasis. The efficient coordination of Wnt and BMP is essential in many developmental processes such as establishment of antero-posterior and dorso-ventral body … Read More

PLoS One. 2020 Mar 25;15(3):e0229170. doi: 10.1371/journal.pone.0229170. ABSTRACT: Surface protein CD20 serves as the critical target of immunotherapy in various B-cell malignancies for decades, however its biological function and regulation remain largely elusive. Better understanding of CD20 function may help … Read More

PhD thesis of Mgr. Pavlína Janovská, Ph.D. was ranked among the 13 most successful dissertations in the Werner von Siemens 2019 competition! This year, 645 applications for diploma and doctoral theses entered the competition, so Pavlina’s placement is a truly … Read More

Our graduate Mgr. Michaela Gregorova has published an article in the new issue of Živa magazine, a popular scientific journal bringing contributions from biological disciplines. Míša published her article “The future in the treatment of chronic lymphocytic leukemia? Inhibition of … Read More

Mgr. Tomáš Gybel´, a doctoral student from the laboratory of prof. Vitezslav Bryja, won the prestigious Brno PhD Talent 2019 scholarship! Tomáš succeeded with his PhD project „Molecular and Functional Analysis of Casein Kinase 1 Biology“.  The scholarship is awarded … Read More

Pavlina Janovska, Ph.D. has been chosen in the selection of noteworthy women scientists at MUNI on the occasion of The International Day of Women and Girls in Science (the 11th day of February) announced by United Nations. Congratulations! See the … Read More

Students of our department have succeeded in the grant competition of the Rector Program!Grants are awarded to outstanding students of Master’s degree programs for research related to their thesis.Congratulations!   The following students received support for their projects: Bc. Eliška … Read More

Cell Communication and Signaling volume 17, Article number: 170 (2019) BACKGROUND: Dishevelled (DVL) is an essential component of the Wnt signaling cascades. The function of DVL is controlled by phosphorylation but the molecular details are missing. DVL3 contains 131 serines and threonines whose … Read More

Theranostics 2020; 10(2):537-552. doi:10.7150/thno.37423 High-grade serous carcinoma of the ovary, fallopian tube, and peritoneum (HGSC) is the deadliest gynecological disease which results in a five-year survival rate of 30% or less. HGSC is characterized by the early and rapid development … Read More

Peťa and Tomek successfully passed their doctoral state exams! Congratulations!

Have a look at the interview with prof. Vítězslav Bryja for the Neuron Fund for Support of Science, which explains prof. Bryja´s research in a clear and very nice way. The interview was created as a part of „Scientists under … Read More

Our group presenting the latest research results at the International Conference Analytical Cytometry 2019 organized by Czech Society for Analytical Cytometry. Great to hear exciting news from the field of flowcytometry!

At the beginning of the semester, we introduced our department to students who are interested in studying at Faculty of Science at Masaryk University. If you couldn’t visit us, don’t worry! Information materials are available online – students looking for … Read More

Masaryk University Technology Transfer Office prepared an interview with Vitezslav Bryja about developing inhibitors of casein kinase 1 in collaboration with Kamil Paruch´s group (Department of Chemistry) that can be used in the future as treatment of chronic lymphocytic leukemia … Read More

Students of our dept. received the Dean´s award for their high-level theses & publication successes! Good job! We wish you a lot of success in your further research!   Awards for outstanding diploma thesis: Michaela Gregorová: Novel casein kinase 1 … Read More

Congratulations! High school student in our laboratory, Martin Zavřel has recently won the 1st place in biology category of Students´ Professional Activities national contest (SOČ) in the South Moravian Region! He succeeded with his work “WNT signaling in the pathogenesis of chronic lymphocytic leukemia” supervised … Read More

Exciting day! Prof. Roel Nusse from Stanford University Medical Center & Howard Hughes Medical Institute, the father of Wnt signaling field, visited Bryjalab today and gave a Mendel lecture within the MU Life Sciences seminar: https://mendellectures.muni.cz/#_lect_back9. Thanks for your visit and great discussion!

One of the main Czech newspapers – „Hospodarske noviny“ reported about Karol Kaiser´s research of long-range transport of biologically active Wnt5A via lipoprotein particles in the cerebrospinal fluid (http://bit.ly/2PYkeK2)! Don´t get confused by a bit misleading title of the interview.  https://archiv.ihned.cz/c1-66573160-bunky-dokazou-rakovinu-po-tele-posilat-na-dalku-zjistili-vedci-z-masarykovy-univerzity-jejich-objev-muze-zlepsit-lecbu-nemoci

Congratulations! Pavlina Janovska, Ph.D. received the rector´s award for outstanding scientists under age of 35 at Masaryk University! Pavlina´s research is focused on CK1 inhibitors and treatment of chronic lymphocytic leukemia, see her publication list here: http://bit.ly/2JmGtc2! See video from … Read More

Magazine M of Masaryk University reports about 2 publication successes of Bryjalab in Nature Communications!: „Buňky spolu komunikují na větší vzdálenost, než se předpokládalo!“ A story about long-range transport of Wnt5A by Karol Kaiser which is an exciting novel view … Read More

Bryjalab continues in the development of methods for the analysis of exosomes: After flow cytometry optimization https://doi.org/10.3402/jev.v4.25530 … & TEM Exosome Analyzer https://doi.org/10.1080/20013078.2018.1560808 … published in Journal of Extracellular Vesicles now presents EV isolation method comparison using proteomic data! Anicka Kotrbova presented her poster Mass spectrometry analysis of  small extracellular … Read More

Interview with our student Kacka Kudlickova about her work in the lab already during her high school studies, lecturing in Bioskop center (bioskop.muni.cz) and organizing a conference for young people: Ceske-nadeje.cz „Středoškolák v laboratoři není sci-fi!“

Vita Bryja presented the casein kinase 1 inhibitors that are being developed in our laboratory together with Kamil Paruch´s team at the international partnering conference BIOEuropeSpring 2019 in Vienna! Fingers crossed for the future cooperations!

Congratulations! Our student Kacka Kudlickova won the shared 1st place in the international contest Beijing Youth Science Creation Competition (BYSCC) in China! Kacka presented her work “Mysterious proteins from RNFT family in intercellular signaling and tumors”.

Today, it is Vita Bryja´s honor to host one of the key inventors of the CRISPR–Cas9 technology – Prof. Emmanuelle Charpentier (Max Planck Unit for the Science of Pathogens, Germany), who is visiting our lab and giving a Mendel lecture “CRISPR-Cas9: a … Read More

Congratulations to our student Kacka Kudlickova! Thanks to Kacka´s great success in Healthcare category of Students´ Professional Activities national contest (SOČ) where she won the 2nd place, now she has been chosen to represent the Czech Republic in the international contest Beijing … Read More

We cordially congratulate to Jakub Harnoš, Ph.D. who has successfully completed his journey to a doctoral degree!And we wish him the BEST OF LUCK in his new postdoc position in New York in Sergei Sokol´s laboratory!

Last week, Masaryk University had the honor to host Prof. Rudolf Jaenisch, who created the first transgenic animal model in history (see Prof. Jaenisch´s biography here). Prof. Rudolf Jaenisch also visited our lab and gave a lecture “Epigenetic Regulation in Development, Aging and … Read More

Last week, Masaryk University had the honor to host the Nobel Prize laureate, Prof. Eric F. Wieschaus, who was awarded the Nobel Prize (1995) in the field of Physiology with Edward B. Lewis and Christiane Nüsslein-Volhard as co-recipients, for their work revealing … Read More

Congratulations to Pavlína Janovská who won the 3rd place in competition SANOFI PRIZE FOR PHARMACY 2018 whose purpose is to award the best PhD research works in experimental biomedical and pharmaceutical research! Pavlina´s great success was noticed by several media: ibrno.cz denik.cz … Read More

Congratulations to Kristína Gömöryová who successfully obtained a Master’s degree and was admitted to PhD study! And congratulations also to our new bachelors who smoothly defended their theses! Miroslav Micka, Nikodém Zezula, Štěpán Čada, Jana Lapinová, Petra Kompaníková

Congratulations to our student Kacka Kudlickova! She won the second place in Healthcare category of Students´ Professional Activities national contest (SOC – Středoškolská odborná činnost)!

Two articles – about czech science and career in science and family life (with contribution of Vita Bryja), were published in Universitas magazine (in czech only): Universitas: Anketa: Co je na české vědě špatně? A jak tu udržet mladé? Universitas: … Read More

We are more than happy that we helped our boss to dig manually the greatest hole in the world #CestaDoStreduZeme #VybagrujteCechy,SlovenskoChceMore #ZerykInLove