Publications 2022 S. Hankeova, N. Van Hul, J. Laznovsky, E. Verboven, K. Mangold, N. Hensens, C. Adori, E. Verhoef, T. Zikmund, F. Dawit, M. Kavkova, J. Salplachta, M. Sjöqvist, B. Johansson, M. Hassan , L. Fredriksson, K. Baumgärtel, V. Bryja , U. Lendahl, A. Jheon, F. Alten, K. Fahnehjelm, B. Fischler, J. Kaiser, E. R. Andersson. Sex differences and risk factors for bleeding in Alagille syndrome . EMBO Mol Med F. Falginella, M. Kravec, M. Drabinová, P. Paclíková, V. Bryja , R. Vácha. Binding of DEP domain to phospholipid membranes: More than just electrostatics . Biochim Biophys Acta Biomembr P. Kompaníková, V. Bryja . Regulation of choroid plexus development and its functions . Cell Mol Life Sci K. Weissová, B. Fafílek, T. Radaszkiewicz, C. Celiker, P. Macháčková, T. Čechová, J. Šebestíková, A. Hampl, V. Bryja , P. Krejčí, T. Bárta. LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reporters . Life Sci Alliance L. Poppova, S. Pavlova, B. Gonzalez, J. Kotaskova, K. Plevova, G. Dumbovic, P. Janovska, V. Bystry, A. Panovska, L. Bezdekova, S. Maslejova, Y. Brychtova, M. Doubek, M. Krzyzankova, M. Borsky, J. Mayer, V. Bryja , S. Alonso, S. Pospisilova. Memory B-cell like chronic lymphocytic leukaemia is associated with specific methylation profile of WNT5A promoter and undetectable expression of WNT5A gene . Epigenetics Z. Dave, O. Vondálová Blanářová, Š. Čada , P. Janovská, N. Zezula, M. Běhal, K. Hanáková, S. Ranjani Ganji, P. Krejci, K. Gömöryová, H. Peschelová, M. Šmída, Z. Zdráhal, Š. Pavlová, J. Kotašková, Š. Pospíšilová, V. Bryja . Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells . Front Cell Dev Biol 2021 M. Micka, V. Bryja . Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways? Handb Exp Pharmacol. Š. Čada, V. Bryja . Local Wnt signalling in the asymmetric migrating vertebrate cells . Semin Cell Dev Biol. T. Radaszkiewicz, M. Nosková, K. Gömöryová, O. Vondálová Blanářová, K. A. Radaszkiewicz, M. Picková, R. Víchová, T. Gybeľ, K. Kaiser, L. Demková, L. Kučerová, T. Bárta, D. Potěšil, Z. Zdráhal, K. Souček, V. Bryja . RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy . Elife P. Paclíková, T. W. Radaszkiewicz, D. Potěšil, J. Harnoš, Z. Zdráhal, V. Bryja . Roles of individual human Dishevelled paralogs in the Wnt signalling pathways . Cell Signal. K. Kaiser, A. Jang, P. Kompaníková, M. P. Lun, J. Procházka, O. Machon, N. Dani, M. Procházková, B. Laurent, D. Gyllborg, R. van Amerongen, R. M. Fame, S. Gupta, F. Wu, R. A. Barker, I. Buková, R. Sedláček, Z. Kozmík, E. Arenas, M. K. Lehtinen* and V. Bryja* . MEIS-WNT5A axis regulates development of 4th ventricle choroid plexus. Development S. Suthon, R. S. Perkins, V. Bryja , G. A. Miranda-Carboni and S. A. Krum. WNT5B in Physiology and Disease . Front Cell Dev Biol. N. Dani, R. H. Herbst, C. McCabe, G. Green, K. Kaiser, J. Head, J. Cui, F. B. Shipley, A. Jang, D. Dionne, L. Nguyen, C. Rodman, S. J. Riesenfeld, J. Prochazka, M. Prochazkova, R. Sedlacek, F. Zhang, V. Bryja , O. Rozenblatt-Rosen, N. Habib, A. Regev, M. K. Lehtinen. A cellular and spatial map of the choroid plexus across brain ventricles and ages . Cell O. Bernatik, P. Paclikova, A. Kotrbova, V. Bryja, L. Cajanek, 2021: Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling . Front Cell Dev Biol. S. Hankeova, J. Salplachta, T. Zikmund, M. Kavkova, N. Van Hul, A. Brinek, V. Smekalova, J. Laznovsky, F. Dawit, J. Jaros, V. Bryja, U. Lendahl, E. Ellis, A. Nemeth, B. Fischler, E. Hannezo, J. Kaiser, E. R. Andersson, 2021: DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome . Elife 2020 P. Janovská, E. Normant, H. Miskin, V. Bryja, 2020: Targeting Casein Kinase 1 (CK1) in Hematological Cancers . Int J Mol Sci. M. Bosakova, S. Abraham, A. Nita, E. Hruba, M. Buchtova, S. P. Taylor, I. Duran, J. Martin, K. Svozilova, T. Barta, M. Varecha, L. Balek, J. Kohoutek, T. Radaszkiewicz, G. Pusapati, V. Bryja, E. Rush, I. Thiffault, D. Nickerson, M. Bamshad, R. Rohatgi, D. Cohn, D. Krakow, P. Krejci, 2020: Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling . EMBO Mol Med. M. Spit , N. Fenderico, I. Jordens, T. Radaszkiewicz, R. Lindeboom, J. Bugter, A. Cristobal, L. Ootes, M. van Osch, E. Janssen, K. Boonekamp, K. Hanakova, D. Potesil, Z. Zdrahal, S. Boj, J.P. Medema, V. Bryja, B.-K. Koo, M. Vermeulen, M. M. Maurice, 2020: RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer . EMBO J. Kaiser K., Bryja V., 2020: Choroid Plexus: The Orchestrator of Long-Range Signalling Within the CNS . Int. J. Mol. Sci. Radaszkiewicz T., Bryja V., 2020: Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells . Cell Commun Signal. Kratzer M.-C., S. F.S. Becker, A. Grund, A. Merks, J. Harnoš, V. Bryja, K. Giehl, J. Kashef*, Annette Borchers*, 2020: The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled . Development Bernatik O., P. Paclíková, R. Sri Ganji, and V. Bryja, 2020: Activity of Smurf2 Ubiquitin Ligase is Regulated by the Wnt Pathway Protein Dishevelled . Cells Kozlova V. , A. Ledererova, A. Ladungova, P. Janovska, P. Kopcil, V. Vakulova, J. Oppelt, V. Bryja, M. Doubek, J. Mayer, S. Pospisilova and M. Smida, 2020: CD20 is dispensable for B-cell receptor signaling but is required for proper actin polymerization, adhesion and migration of malignant B cells . PLoS One. Kotrbová A, Ovesná P, Gybel’ T, Radaszkiewicz T, Bednaříková M, Hausnerová J, Jandáková E, Minář L, Crha I, Weinberger V, Záveský L, Bryja V, Pospíchalová V., 2020: WNT signaling inducing activity in ascites predicts poor outcome in ovarian cancer . Theranostics 2019 Karol Kaiser, Daniel Gyllborg, Jan Procházka, Alena Salašová, Petra Kompaníková, Francisco Lamus Molina, Rocio Laguna-Goya, Tomasz Radaszkiewicz, Jakub Harnoš, Michaela Procházková, David Potěšil, Roger A. Barker, Ángel Gato Casado, Zbyněk Zdráhal, Radislav Sedláček, Ernest Arenas, J. Carlos Villaescusa & Vítězslav Bryja, 2019: WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis . Nature Communications Kotrbová A., Štěpka K., Maška M., Pálenik JJ., Ilkovics L., Klemová D., Kravec M., Hubatka F., Dave Z., Hampl A., Bryja V., Matula P., Pospíchalová V., 2019: TEM ExosomeAnalyzer: a computer-assisted software tool for quantitative evaluation of extracellular vesicles in transmission electron microscopy images . J Extracell Vesicles Jakub Harnoš, Maria Consuelo Alonso Cañizal, Miroslav Jurásek, Jitender Kumar, Cornelia Holler, Alexandra Schambony, Kateřina Hanáková, Ondřej Bernatík, Zbyněk Zdráhal, Kristína Gömöryová, Tomáš Gybeľ, Tomasz Witold Radaszkiewicz, Marek Kravec, Lukáš Trantírek, Jan Ryneš, Zankruti Dave, Ana Iris Fernández-Llamazares, Robert Vácha, Konstantinos Tripsianes, Carsten Hoffmann & Vítězslav Bryja, 2019: Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1 . Nature Communications Hanáková K, Bernatík O, Kravec M, Micka M, Kumar J, Harnoš J, Ovesná P, Paclíková P, Rádsetoulal M, Potěšil D, Tripsianes K, Čajánek L, Zdráhal Z, Bryja V., 2019: Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs . Cell Communication and Signaling 2018 Plešingerová H, Janovská P, Mishra A, Smyčková L, Poppová L, Libra A, Plevová K, Ovesná P, Radová L, Doubek M, Pavlová Š, Pospíšilová Š, Bryja V., 2018: Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia . Haematologica Strakova K, Kowalski-Jahn M, Gybel T, Valnohova J, Dhople VM, Harnos J, Bernatik O, Ganji RS, Zdrahal Z, Mulder J, Lindskog C, Bryja V, Schulte, 2018: Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization . J Biol Chem Analysis of AXIN1 binding interfaces by peptide microarrays . J Biol Chem Lee Y, Kim NH, Cho ES, Yang JH, Cha YH, Kang HE, Yun JS, Cho SB, Lee SH, Paclikova P, Radaszkiewicz TW, Bryja V, Kang CG, Yuk YS, Cha SY, Kim SY, Kim HS, Yook JI, 2018: Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner . Nat Communications Remco A. Mentink, Lorenzo Rella, Tomasz W. Radaszkiewicz, Tomáš Gybel, Marco C. Betist, Vitězslav Bryja, Hendrik C. Korswagen, 2018: The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism . PLOS Genetics Janovska P.; Verner J.; Kohoutek J.; Bryjova L.; Gregorova M.; Dzimkova M.; Skabrahova H.; Radaszkiewicz T.; Ovesna P.; Vondalova Blanarova O.; Nemcova T.; Hoferova Z; Vasickova K.; Smyckova L.; Egle A.; Pavlova S.; Poppova L.; Plevova K.; Pospisilova S.; Bryja V., 2018: Casein Kinase 1 is a Therapeutic Target in Chronic Lymphocytic Leukemia . Blood 2017 Bryja V., Červenka I, Čajánek L., 2017: The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? . Crit Rev Biochem Mol Biol Andersson ER, Chivukula IV, Hankeova S, Sjöqvist M, Tsoi YL, Ramsköld D, Masek J, Elmansuri A, Hoogendoorn A, Vazquez E, Storvall H, Netušilová J, Huch M, Fischler B, Ellis E, Contreras A, Nemeth A, Chien KC, Clevers H, Sandberg R, Bryja V, Lendahl U., 2017: Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations . Gastroenterology Boström J, Sramkova Z, Salašová A, Johard H, Mahdessian D, Fedr R, Marks C, Medalová J, Souček K, Lundberg E, Linnarsson S, Bryja V, Sekyrova P, Altun M, Andäng M., 2017: Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells . PLoS One Fatima I, El-Ayachi I, Taotao L, Lillo MA, Krutilina R, Seagroves TN, Radaszkiewicz TW, Hutnan M, Bryja V, Krum SA, Rivas F, Miranda-Carboni GA., 2017: The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer . PLoS One Schulte G, Bryja V., 2017: WNT signalling: mechanisms and therapeutic opportunities . Br J Pharmacol Strakova K, Matricon P, Yokota C, Arthofer E, Bernatik O, Rodriguez D, Arenas E, Carlsson J, Bryja V, Schulte G., 2017: The tyrosine Y2502.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled . Cell Signal Salašová A, Yokota C, Potěšil D, Zdráhal Z, Bryja V., Arenas E., 2017: A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway . Mol Neurodegener Paclíková P, Bernatík O, Radaszkiewicz TW, Bryja V., 2017: N-terminal part of Dishevelled DEP domain is required for Wnt/β-catenin signaling in mammalian cells . Mol Cell Biol Bernatik O, Radaszkiewicz T, Behal M, Dave Z, Witte F, Mahl A, Cernohorsky NH, Krejci P, Stricker S, Bryja V., 2017: A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation . Front Cell Dev Biol Putnová I, Dosedělová H, Bryja V., Landová M, Buchtová M, Štembírek J., 2017: Angled Growth of the Dental Lamina Is Accompanied by Asymmetrical Expression of the WNT Pathway Receptor Frizzled 6 . Front Physiol H. Plešingerová, Z. Librová, K. Plevová, A. Libra, B. Tichý, H. Skuhrová-Francová, F. Vrbacký, L. Smolej, J. Mayer, V. Bryja, M. Doubek, Šárka Pospíšilová, 2017: COBLL1, LPL and ZAP70 expression defines prognostic subgroups of chronic lymphocytic leukemia patients with high accuracy and correlates with IGHV mutational status . Leuk Lymphoma F. Linke, S. Zaunig, M. M. Nietert, F. von Bonin, S. Lutz, C. Dullin, P. Janovská, T. Beissbarth, F. Alves, V. Bryja, T. Pukrop, L. Trümper, J. Wilting, D. Kube, 2017: WNT5A: a motility-promoting factor in Hodgkin lymphoma . Oncogene K. Štěpka, M. Maška, J. J. Pálenik, V. Pospíchalová, A. Kotrbová, L. Ilkovics, D. Klemová, A. Hampl, V. Bryja, P. Matula, 2017: Automatic Detection and Segmentation of Exosomes in Transmission Electron Microscopy . Computer Vision – ECCV 2016 Workshops. ECCV 2016. Lecture Notes in Computer Science Linke F, Harenberg M, Nietert MM, Zaunig S, von Bonin F, Arlt A, Szczepanowski M, Weich HA, Lutz S, Dullin C, Janovská P, Krafčíková M, Trantírek L, Ovesná P, Klapper W, Beissbarth T, Alves F, Bryja V, Trümper L, Wilting J, Kube D., 2017: Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma . Leukemia 2016 Kotašková J, Pavlová Š, Greif I, Stehlíková O, Plevová K, Janovská P, Brychtová Y, Doubek M, Pospíšilová Š, Bryja V., 2016: ROR1-based immunomagnetic protocol allows efficient separation of CLL and healthy B cells . Br J Haematol L. Poppova, P. Janovska, K. Plevova, L. Radova, H. Plesingerova, M. Borsky, J. Kotaskova, B. Kantorova, M. Hlozkova, J. Figulova, Y. Brychtova, M. Machalova, M. Urik, M. Doubek, A. Kozubik, S. Pospisilova, S.Pavlova, V. Bryja, 2016: Decreased WNT3 expression in chronic lymphocytic leukaemia is a hallmark of disease progression and identifies patients with worse prognosis in the subgroup with mutated IGHV . Br J Haematol I. Cervenka, J. Valnohova, O. Bernatik, J. Harnoš, M. Radsetoulal, K. Sedova, K. Hanakova, D. Potesil, M. Sedlackova, A. Salasova, Z. Steinhart, S. Angers, G. Schulte, A. Hampl, Z. Zdrahal, V. Bryja., 2016: Dishevelled is a NEK2 substrate controlling dynamics of centrosomal linker proteins . Proc Natl Acad Sci USA Janovska P, Poppova L, Plevova K, Plesingerova H, Behal M, Kaucka M, Ovesna P, Hlozkova M, Borsky M, Stehlikova O, Brychtova Y, Doubek M, Machalova M, Baskar S, Kozubik A, Pospisilova S, Pavlova S, Bryja V., 2016: Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia . Clin Cancer Res Zemanova J, Hylse O, Collakova J, Vesely P, Oltova A, Borsky M, Zaprazna K, Kasparkova M, Janovska P, Verner J, Kohoutek J, Dzimkova M, Bryja V, Jaskova Z, Brychtova Y, Paruch K, Trbusek M., 2016: Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells . Oncotarget 2015 Pospichalova V, Svoboda J, Dave Z, Kotrbova A, Kaiser K, Klemova D, Ilkovics L, Hampl A, Crha I, Jandakova E, Minar L, Weinberger V, Bryja V., 2015: Simplified protocol for flow cytometry analysis of fluorescently labeled exosomes and microvesicles using dedicated flow cytometer . J Extracell Vesicles Mo L, Pospichalova V, Huang Z, Murphy SK, Payne S, Wang F, Kennedy M, Cianciolo GJ, Bryja V, Pizzo SV, Bachelder RE., 2015: Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells . PLoS One Buchtova M, Oralova V, Aklian A, Masek J, Vesela I, Ouyang Z, Obadalova T, Konecna Z, Spoustova T, Pospisilova T, Matula P, Varecha M, Balek L, Gudernova I, Jelinkova I, Duran I, Cervenkova I, Murakami S, Kozubik A, Dvorak P, Bryja V, Krejci P., 2015: Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage . Biochim Biophys Acta Ekumi KM, Paculova H, Lenasi T, Pospichalova V, Bösken CA, Rybarikova J, Bryja V, Geyer M, Blazek D, Barboric M., 2015: Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex . Nucleic Acids Res Kaucká M, Petersen J, Janovská P, Radaszkiewicz T, Smyčková L, Daulat AM, Borg JP, Schulte G, Bryja V., 2015: Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway . Cell Commun Signal 2014 Bernatík O, Šedová K, Schille C, Ganji RS, Červenka I, Trantírek L, Schambony A, Zdráhal Z, Bryja V., 2014: Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1ϵ and frizzled5 . J Biol Chem de Groot RE, Ganji RS, Bernatik O, Lloyd-Lewis B, Seipel K, Šedová K, Zdráhal Z, Dhople VM, Dale TC, Korswagen HC, Bryja V., 2014: Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway . Sci Signal Kilander MB, Petersen J, Andressen KW, Ganji RS, Levy FO, Schuster J, Dahl N, Bryja V, Schulte G., 2014: Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6 . FASEB J Seitz K, Dürsch V, Harnoš J, Bryja V, Gentzel M, Schambony A., 2014: β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation . PLoS One Kříž V, Pospíchalová V, Masek J, Kilander MB, Slavík J, Tanneberger K, Schulte G, Machala M, Kozubík A, Behrens J, Bryja V., 2014: β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein . J Biol Chem 2013 Čajánek L, Ganji RS, Henriques-Oliveira C, Theofilopoulos S, Koník P, Bryja V, Arenas E., 2013: Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons . Mol Cell Biol Soldano A, Okray Z, Janovska P, Tmejová K, Reynaud E, Claeys A, Yan J, Atak ZK, De Strooper B, Dura JM, Bryja V, Hassan BA., 2013: The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling . PLoS Biol Kaucká M, Plevová K, Pavlová S, Janovská P, Mishra A, Verner J, Procházková J, Krejcí P, Kotasková J, Ovesná P, Tichy B, Brychtová Y, Doubek M, Kozubík A, Mayer J, Pospísilová S, Bryja V., 2013: The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration . Cancer Res Andersson ER, Saltó C, Villaescusa JC, Cajanek L, Yang S, Bryjova L, Nagy II, Vainio SJ, Ramirez C, Bryja V, Arenas E., 2013: Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells . Proc Natl Acad Sci USA . 2012 Chaki M, Airik R, Ghosh AK, Giles RH, Chen R, Slaats GG, Wang H, Hurd TW, Zhou W, Cluckey A, Gee HY, Ramaswami G, Hong CJ, Hamilton BA, Cervenka I, Ganji RS, Bryja V, Arts HH, van Reeuwijk J, Oud MM, Letteboer SJ, Roepman R, Husson H, Ibraghimov-Beskrovnaya O, Yasunaga T, Walz G, Eley L, Sayer JA, Schermer B, Liebau MC, Benzing T, Le Corre S, Drummond I, Janssen S, Allen SJ, Natarajan S, O’Toole JF, Attanasio M, Saunier S, Antignac C, Koenekoop RK, Ren H, Lopez I, Nayir A, Stoetzel C, Dollfus H, Massoudi R, Gleeson JG, Andreoli SP, Doherty DG, Lindstrad A, Golzio C, Katsanis N, Pape L, Abboud EB, Al-Rajhi AA, Lewis RA, Omran H, Lee EY, Wang S, Sekiguchi JM, Saunders R, Johnson CA, Garner E, Vanselow K, Andersen JS, Shlomai J, Nurnberg G, Nurnberg P, Levy S, Smogorzewska A, Otto EA, Hildebrandt F., 2012: Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling . Cell Krejci P, Aklian A, Kaucka M, Sevcikova E, Prochazkova J, Masek JK, Mikolka P, Pospisilova T, Spoustova T, Weis M, Paznekas WA, Wolf JH, Gutkind JS, Wilcox WR, Kozubik A, Jabs EW, Bryja V, Salazar L, Vesela I, Balek L., 2012: Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation . PLoS One Kele J, Andersson ER, Villaescusa JC, Cajanek L, Parish CL, Bonilla S, Toledo EM, Bryja V, Rubin JS, Shimono A, Arenas E., 2012: SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells . Stem Cells 2011 Kaucká M, Krejčí P, Plevová K, Pavlová S, Procházková J, Janovská P, Valnohová J, Kozubík A, Pospíšilová S, Bryja V., 2011: Post-translational modifications regulate signalling by Ror1 . Acta Physiol Tanneberger K, Pfister AS, Brauburger K, Schneikert J, Hadjihannas MV, Kriz V, Schulte G, Bryja V, Behrens J., 2011: Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation . EMBO J Bernatik O, Ganji RS, Dijksterhuis JP, Konik P, Cervenka I, Polonio T, Krejci P, Schulte G, Bryja V., 2011: Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases . J Biol Chem Kilander MB, Dijksterhuis JP, Ganji RS, Bryja V, Schulte G., 2011: WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins . Cell Signal Červenka I, Wolf J, Mašek J, Krejci P, Wilcox WR, Kozubík A, Schulte G, Gutkind JS, Bryja V., 2011: Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6 . Mol Cell Biol Hrubá E, Vondráček J, Líbalová H, Topinka J, Bryja V, Souček K, Machala M., 2011: Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands . Toxicol Lett Procházková J, Kabátková M, Bryja V, Umannová L, Bernatík O, Kozubík A, Machala M, Vondrácek J., 2011: The interplay of the aryl hydrocarbon receptor and β-catenin alters both AhR-dependent transcription and Wnt/β-catenin signaling in liver progenitors . Toxicol Sci Tanneberger K, Pfister AS, Kriz V, Bryja V, Schambony A, Behrens J., 2011: Structural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1) . J Biol Chem. 2010 Cajanek L, Adlerz L, Bryja V, Arenas E., 2010: WNT unrelated activities in commercially available preparations of recombinant WNT3a . J Cell Biochem Foldynová-Trantírková S, Sekyrová P, Tmejová K, Brumovská E, Bernatík O, Blankenfeldt W, Krejcí P, Kozubík A, Dolezal T, Trantírek L, Bryja V., 2010: Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration . Breast Cancer Res
Book Chapter
Patents BRYJA, Vítězslav, JANOVSKÁ, Pavlína, GREGOROVÁ, Michaela, NĚMEC, Václav, KHIRSARIYA, Prashant, PARUCH, Kamil, 2019: New 4-(1H-imidazol-5-yl)-1H-pyrrolo(2,3-b)pyridine derivatives used to treat leukemia e.g. chronic lymphocytic leukemia, lymphoma e.g. Burkitt lymphoma, mantle cell lymphoma or solid tumors e.g. breast cancer, melanoma and prostate cancer . PCT: WO2019185631-A1, Application: EP164938. Casein kinase 1 inhibitors for the treatment of B-cell chronic lymphocytic leukemia . PCT: WO2014023271 (A1) 2014-02-13, National Patents: CZ20120538 (A3) 2014-02-19, CA2876908 (C) 2016-11-08, European Patent: EP2882437 (B1) 2016-12-14, Applications: US2015209354 (A1) 2015-07-30. Method of determination of diagnosis and prognosis in patients with B-cell chronic lymphocytic leukemia and oligonucleotides for use in this method . PCT: WO2011015162 (A2) 2011-02-10, National Patents: CZ303555 (B6) 2012-12-05, US9057106 (B2) 2015-06-16, Application: EP2462243 (A2) 2012-06-13.
Utility Models PLEVOVÁ, Karla, Hana PLEŠINGEROVÁ, Antonín LIBRA, Zuzana JURČÍČKOVÁ, Jana KOTAŠKOVÁ, Šárka PAVLOVÁ, Vítězslav BRYJA, Šárka POSPÍŠILOVÁ and Alois KOZUBÍK, 2014: Sada pro stanovení prognózy chronické lymfocytární leukémie (Kit to determine prognosis of chronic lymphocytic leukemia) . Application: 2014-30165.
