Reduced ER–mitochondria connectivity promotes neuroblastoma multidrug resistance. The EMBO Journal (2022)41:e108272
Jorida Çoku, David M Booth, Jan Skoda, Madison C Pedrotty, Jennifer Vogel, Kangning Liu, Annette Vu, Erica L Carpenter, Jamie C Ye, Michelle A Chen, Peter Dunbar, Elizabeth Scadden, Taekyung D Yun, Eiko Nakamaru-Ogiso, Estela Area-Gomez, Yimei Li, Kelly C Goldsmith, C Patrick Reynolds, Gyorgy Hajnoczky, Michael D Hogarty
Iron-Chelation Treatment by Novel Thiosemicarbazone Targets Major Signaling Pathways in Neuroblastoma. Int. J. Mol. Sci. 2022, 23(1): 376.
Peter Macsek, Jan Skoda,Maria Krchniakova, Jakub Neradil, Renata Veselska
Tumour Microenvironment Stress Promotes the Development of Drug Resistance. Antioxidants 2021, 10(11): 1801.
Nicole A. Seebacher, Maria Krchniakova, Alexandra E. Stacy, Jan Skoda, Patric J. Jansson.
Noncanonical roles of p53 in cancer stemness and their implications in sarcomas. Cancer Letters 2022, 525: 131-145.
Lucie Curylova, Helena Ramos, Lucília Saraiva, Jan Skoda.
Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor. Pediatr Blood Cancer 2021, e29401.
Andrew D. Woods, Noah E. Berlow, Michael V. Ortiz, Filemon Dela Cruz, Armaan Siddiquee, Diego F. Coutinho, Reshma Purohit, Katherine E. Tranbarger Freier, Joel E. Michalek, Melvin Lathara, Kevin Matlock, Ganapati Srivivasa, Brigitte Royer-Pokora, Renata Veselska, Andrew L. Kung, Charles Keller
Novel New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRβ Signaling. Cancers 2021, 12:3781.
Michal Mahdal, Jakub Neradil, Peter Mudry, Silvia Paukovcekova, Iva Staniczkova Zambo, Jiri Urban, Peter Macsek, Lukas Pazourek, Tomas Tomas and Renata Veselska
A selective p53 activator and anticancer agent to improve colorectal cancer therapy. Cell Rep 2021, 35(2):1089.
Helena Ramos, Maria I L Soares, Joana Silva, Liliana Raimundo, Juliana Calheiros, Célia Gomes, Flávio Reis, Filipe A Monteiro, Cláudia Nunes, Salette Reis, Bartolomeo Bosco, Silvano Piazza, Lucília Domingues, Petr Chlapek, Petr Vlcek, Pavel Fabian, Ana Teresa Rajado, A T P Carvalho, Renata Veselska, Alberto Inga, Teresa M V D Pinho E Melo, Lucília Saraiva
Our diploma student Bc. Aneta Vaskova ranked among the 31 master’s students who were awarded grant funding for her diploma project Analysis of NTRK signaling in neuroblastoma cell lines, which she conducts under the supervision by Assoc. prof. Jakub Neradil.
Congratulations and we wish you success in your research!
Our doctoral student Mgr. Lucie Curylova was awarded the prestigious three-year scholarship Brno Ph.D. talent 2020. In the competition of 130 Ph.D. students, she succeeded with her project „The p53 family proteins in the regulation of stemness in pediatric sarcomas“, whose goal is to verify the strategy of stemness factors inhibition through p53 reactivation, which might prove a promising treatment of aggressive pediatric sarcomas.
Another of our doctoral student, Mgr. Karolina Borankova, was awarded the Brno Ph.D. Talent Finalist, ranking among the best 35 attendees of the competition. Both Lucie and Karolina conduct their dissertation thesis under the supervision by Dr. Jan Skoda in our laboratory.
Congratulations on your fantastic achievement!
Paukovcekova et al.: Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms. Cancers 2020, 12:3781.
